Androgens and spermatogenesis: lessons from transgenic mouse models
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چکیده
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Androgens and spermatogenesis: lessons from transgenic mouse models
Transgenic mouse models have contributed considerably to our understanding of the cellular and molecular mechanisms by which androgens control spermatogenesis. Cell-selective ablation of the androgen receptor (AR) in Sertoli cells (SC) results in a complete block in meiosis and unambiguously identifies the SC as the main cellular mediator of the effects of androgens on spermatogenesis. This con...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2010
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2009.0117